Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib
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Serum prolactin level in psoriasis: Is it really higher than in healthy individuals?
Background: Psoriasis is a chronic immune-mediated skin diseasewith a genetic predisposition. Prolactin may contribute to psoriasispathogenesis. However, there has been a debate over the serumlevel of prolactin in psoriatic patients. The aim of this study was todescribe the role of serum prolactin in the pathogenesis of psoriasisMethod: The serum prolactin level was measured in 45 patientswith ...
متن کاملA dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division.
Recently, the FtsZ protein, which is known as a key component in bacterial cell division, was reported to be involved in mitochondrial division in algae. In yeast and animals, however, mitochondrial fission depends on the dynamin-like proteins Dnm1p and Drp1, respectively, whereas in green plants, no potential mitochondrial division genes have been identified. BLAST searches of the nuclear and ...
متن کاملis the prevalence of celiac disease higher than the general population in inflammatory bowel diseaese?
background: in some studies inflammatory bowel disease (ibd) and celiac disease were considered to be associated and some belive that this association may influence the prognosis of ibd. however, there is a cosiderable controversy regarding this association. therefore ,we aimed to assess the association of these two common digestive diseases and evaluate the complications of this association. m...
متن کاملExposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress
Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...
متن کاملCryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis.
BACKGROUND Whereas studies have revealed that the cryopreservation of human semen increases sperm DNA fragmentation, the mechanisms involved in this type of cryo-injury are largely unknown. Elucidation of these mechanisms may provide insight into preventing such injury. METHODS We obtained 60 semen samples from 60 men and conducted experiments to determine the cause of cryopreservation-induce...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2020
ISSN: 2213-2317
DOI: 10.1016/j.redox.2020.101502